The effects of Pr substitution on the structural and the superconducting properties for Pb-based 1201 cuprates with compositions of (Pb 0.5-x Pr x Cd 0.5 )SrLaCuO z ( 0 ≤ x ≤ 0.25) and (Pb 0.45 Pr 0.05 Cd 0.5 )(Sr 1-y La 1+y )CuO z (0 ≤ y ≤ 0.1) were investigated. It is found that T c decreases as the Pr-doping content x increases in the (Pb 0.5-x Pr x Cd 0.5 )SrLaCuO z samples, whereas T c of (Pb 0.45 Pr 0.05 Cd 0.5 ) (Sr 1-y La 1+y )CuO z samples increases as the La-doping content y increases. The experimental results were discussed in connection with the change in hole concentration of the samples.