In this article, an analytical method is developed to obtain the response of magnetothermoelastic stress and perturbation of the magnetic field vector for a thick-walled spherical functionally graded materials (FGM) vessel. The vessel, which is placed in a uniform magnetic field, is subjected to an internal pressure and transient temperature gradient. Using the Hankel and Laplace transform techniques, the dynamic equation of magnetothermoelastic is solved and the radial and circumferential stresses as well as the perturbation of the magnetic field vector for a typical material are obtained. Moreover, the effect of magnetic field vector and material inhomogeneity on the stresses is investigated.Keywords Magnetothermoelasticity · Functionally graded material · Thick hollow sphere · Perturbation of magnetic field vector · Transient response List of symbols U , u r displacement vector and radial displacement (m), σ rr , σ θθ radial and circumferential stresses (N/m 2 ) λ 0 , G 0 , γ 0 , ρ 0 , and Lame's constant (N/m 2 ), shear modulus (N/m 2 ), thermal µ 0 modulus (N/Km 2 ), mass density (kg/m 3 ) and magnetic permeability coefficient (H/m), respectively m material grading exponent r radius (m) T (r, t) temperature change (K) t, a, b time (s), inner and outer radii of the FGM hollow sphere (m) H , h magnetic intensity vector, perturbation of magnetic field vector J electric current density vector e perturbation of electric field vector f φφ Lorentz's force (kg/m 2 , s 2 ) P i (t), P o (t) internal and external pressure of FGM hollow sphere (N/m 2 ) u r 0 (r ), v r 0 (r ) initial radial displacement (m), initial speed (m/s) V e elastic wave speed of homogeneous sphere (m/s) V t magnetothermoelastic wave speed (m/s) ω natural frequency of the FGM hollow sphere (1/s)