Layer poultry business is a prospective business due to meeting the need for animal protein from eggs. The average consumption of eggs is 2,152 kg per capita per week. These promising business prospects were not accompanied by an increase in the productivity of laying hens. Abnormal conditions such as cases of poultry disease will plunge the supply of eggs into a drop. One disease that is considerably popular in laying birds is Egg Drop Syndrome (EDS). This review aims to examine the EDS handling strategies in laying birds to prevent decreased egg production. Materials and methods through literature study. Some strategies that farmers can take to prevent EDS are vaccination, maintaining sanitation and cleanliness of pond land, including biosecurity, and using herbs as feed additives.