ChemInform Abstract Twenty-five thioxoquinazolinones such as (I) are S-alkylated with ethyl bromide (II) and subsequently coupled and rearranged with hydrazine hydrate (IV) to produce the title compounds (V).

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ChemInform Abstract Two methods of preparing the title compounds (III) are tested.

Synthesis of 3-Heteroaryl-4-oxo-2-thioxo-and 3-Heteroaryl-2,4-dioxo-1, 2,3,4-tetrahydroquinazolines.-The anthranilic acid esters (I) are transformed to the isothiocyanates (III) which are coupled with the arylamines (IV) to give the 2-thioxo-4-quinazolinones (V). Treatment of some representatives of (V) with hydrogen peroxide yields the diones (VI). -(GRAEFE, I.; KOTTKE, K.; KUEHMSTEDT, H.; KNOKE, D.; Pharmazie 45 (1990) 7, 530-531; Fachber. Pharm., Ernst-Moritz-Arndt-Univ., O-2200 Greifswald, Fed. Rep. Ger.; DE)

Die durch Reaktion der Mercapto‐aryl‐chinazolone (I) mit Hydrazinhydrat (II) zugänglichen Hydrazino‐aryl‐chinazolone (III) lassen sich mit den Verbindungen (IV) in hohen Ausbeuten zu den Triazolochinazolonen (V) kondensieren.