INTRODUCTIONPolycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in infertile women. Infertility affects 40% of women with PCOS.1 Polycystic ovary syndrome (PCOS), a relatively common reproductive endocrine disorder often associated with high endogenous LH secretion, menstrual cycle disorders, infertility and high rates of spontaneous abortion, was considered the paradigm condition that proved the potential untoward actions of LH.Raised tonic levels of luteinizing hormone (LH) is one of the main endocrinological disturbances in PCOS patients.2 This inappropriate secretion of LH seems to affect both fertility and pregnancy outcomes of PCOS women. Increased production of androgens associated with high LH concentrations, coupled with their inefficient aromatization to estrogens related to the low FSH levels in PCOS patients, results in local androgen excess and oestrogen deficit within the ovary.3 This would constitute a potent androgenic environment for the follicle leading to cessation of follicular growth. This ABSTRACT Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in infertile women. Raised tonic levels of luteinizing hormone (LH) is one of the main endocrinological disturbances in PCOS patients. Objective of present study was to evaluate the effect of baseline serum luteinizing hormone levels on follicular development, ovulation and conception and pregnancy outcome in infertile patients with PCOS. Methods: This is a prospective study conducted on 50 consecutive infertile patients with PCOS. Baseline Day 2 serum luteinizing hormone concentration was done in selected patients. Ovulation induction was done with clomiphene citrate 100 mg from Day 3 to Day 7 of the cycle. Then patients were monitored for follicular development, ovulation, conception and early pregnancy loss. Results: The mean age of the patients is 25±3.6 yrs. The average duration of infertility is 5.4 yrs (2-10). The mean basal serum LH concentration in patients who ovulated was significantly low (5.6 IU) in comparison with patients who did not ovulate (10.1 IU). The mean basal serum LH concentration in patients who conceived was 3.9 IU in comparison with patients who did not conceive (5.9 IU) which was statistically significant (p=0.04). Out of 15 patients who conceived, 3 patients (20%) had early pregnancy loss. Conclusions: Tonic hyper secretion of LH results in premature oocyte maturation, causing the problems with fertilization and miscarriage. Inappropriately raised LH appears to have deleterious effects on the pregnancy outcome.

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Background: The birth of a newborn after twenty-eight completed weeks of gestation weighing 1,000 gm or more, with baby showing no signs of life after delivery is a still born’’. Such death includes both antepartum and intrapartum death. Stillbirths (SB) are the largest contributor to perinatal mortality. Of the estimated 3 million stillbirths which occur yearly, the vast majority are in developing countries, with rates in many developing countries ten-fold higher than elsewhere.Methods: Descriptive (cross sectional) study was conducted at tertiary referral hospital in rural area of Maharashtra from September 2015 to August 2017. Out of total 3235 deliveries during study period 64 mothers giving birth to 66 cases of still birth (2 cases of twins) satisfied the inclusion criteria and studied to find out prevalence, causes and high-risk factor association with stillbirth.Results: Stillbirth rate in our study was 20.4/1000 deliveries. 56.25% patients were in the 21-25 years age group.9.3% were illiterate while 57.81% had education below 12th standard. Most patients were from low socioeconomic status and 57.81% were unregistered. Stillbirth was more common in Para (2-4), premature baby and with male sex preponderance in our study. Most patients 90.62% were delivered vaginally. Preeclmpsia, Abruption, Anaemia were common high-risk factor associated with stillbirth.54.6% cases were unexplained stillbirth while IUGR was noted in 23.4% cases and other causes noted were prematurity, congenital anomaly, cord and placental causes were found in our study.Conclusions: A significant proportion of stillbirths are preventable by adequate antenatal care. Female literacy and health education, adequate antenatal care, identification of high-risk cases, and timely referral needs to be emphasized among the medical and paramedical personnel at the first point of contact with the pregnant women.