Disturbances of micturition are important in multiple sclerosis, not only because of their high incidence, the amount of discomfort and embarrassment they cause, and their contribution to the mortality of the disease, but because control of the excretory functions is the most important single factor which determines the patient's admission to hospital. Under satisfactory home conditions many patients with this disease can remain with their families for many years, but the development of urinary retention demands urgent admission to hospital, while incontinence very often necessitates long-terminstitutional care.Estimates of the prevalence of bladder symptoms in multiple sclerosis vary considerably, but disparities have arisen chiefly because figures have been based on quite differently selected groups of patients. Bladder dysfunction as a presenting symptom was described in 5% of Muller's (1949)

The association of eosinophilia and Löffler’s endomyocardial fibrosis with acute lymphoblastic leukemia in a 9-yr-old boy is reported. During the illness, there were three leukemic relapses, each preceded by eosinophilia which subsided upon induction of remission. It is suggested that the eosinophilia in this case was not "eosinophilic leukemia," but more likely a nonneoplastic response to an antigenic stimulus from the leukemic process.

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