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ABSTRACT. Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unrelated mainland northern Chinese individuals: 96 nAMD patients, 92 PCV patients, and 96 controls. Six single TLR3 is not associated with nAMD and PCV nucleotide polymorphisms were identified: rs5743303, rs5743305, rs5743312, rs3775291, rs3775290, and rs6830345. The distribution of TLR3 genotypes for nAMD and PCV was not significantly different compared with normal controls. This study indicates that the TLR3 gene polymorphism is not associated with nAMD and PCV in northern Chinese patients.

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A continuous-wave (CW) heavy-ion radio frequency quadrupole (RFQ) has been designed to accelerate radioactive beams from the Beijing Isotope Separation On-Line (BISOL) facility. This RFQ will accelerate high-charge-state ions such as 132 Sn 21+ from 3 keV/u to 300 keV/u with a vane length of 3.77 m at a frequency of 81.25 MHz. The transmission efficiency reached 98.1% in simulation. The output longitudinal normalized rms emittance is 0.31 keV/u•ns. Tolerance analysis shows that this RFQ can handle a wide range of non-ideal beams while retaining a relatively high transmission efficiency and low longitudinal emittance. In order to increase the intensity of the radioactive ion beams (RIB), this RFQ will accelerate multi-charge-state beams simultaneously. In the case of the tin beam (Sn), we have studied the transmission of adjacent charge state beams and multi-charge-state beams in this RFQ. The transmission efficiency and output transverse beam quality of the multi-charge-state beams are close to the results of the single-charge-state beam, but the output longitudinal emittance is larger. For the radio frequency (RF) structural design, we have compared different types of RFQ, including an IH RFQ, a 4-rod RFQ and a 4-vane RFQ. We have selected a 4-vane RFQ design with dipole stablizer rods, due to the considerations of power consumption, the flatness of electric field, cooling convenience and machining efficiency. We have performed full 3D simulations with multi-physics analysis. K: Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics); Beam dynamics 1Corresponding author.

The Accelerator-based Boron Neutron Capture Therapy (AB-BNCT) is being established worldwide as a future modality to start an era of in-hospital facilities. The most popular reaction for AB-BNCT is 7Li(p, n)7Be and high-flux neutron beams can be produced by bombarding lithium targets with low-energy proton beams. We chose the combined acceleration structure of Radio Frequency Quadrupole linac (RFQ) and Cross-bar H-mode DTL (CH-DTL) considering the compactness of the structure and the adjustment of output energy. The CW proton beam could be accelerated to 1.8 MeV by one RFQ cavity, and then to the final energy by one CH-DTL cavity. The output beam energy can be adjusted in the range of 2.2 MeV to 3.0 MeV with small beam loss and high beam quality, which could be achieved by controlling the feed power and RF phase of the CH-DTL. The variation of beam energy can meet requirements of the BNCT in treating tumors of different depths without adjusting structure of beam shaping assembly (BSA). The beam dynamics of the RFQ and DTL were completed to meet all requirements and the energy stability and adjustment method of output beam were investigated. In addition, we also performed the start-to-end beam tracking and error sensitivity analysis at last.