ABSTRACT. We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Odds ratios and their corresponding 95% confidence intervals were used to assess the influence of TGFB1 rs4803455, rs1800469, and rs1800470 on metastatic brain tumors. We found that cases were more likely to have a later disease stage when compared with control subjects, without brain metastasis. Individuals carrying the TGFB1 rs1800469 TT and CT+TT genotypes had an increased risk of developing brain metastasis compared with the rs1800469 CC genotype. Moreover, a significant interaction was observed between the rs1800469 polymorphism and disease stage. However, no significant association between polymorphisms rs4803455 and rs1800470 and the risk of developing brain metastasis were observed. We found that the TGFB1 rs1800469 polymorphism may be predictive biomarker for the risk of developing brain metastasis in non-small cell (2015) lung cancer patients.

Objective This study aimed to examine the association between cysteine ​​C and Herpes zoster (HZ). Method We acquired data from the MR Base database and used Mendelian randomization (MR) to evaluate the causal association between cysteine ​​C and HZ. Results We selected five single nucleotide polymorphisms from genome-wide association studies that were significantly associated with both cysteine ​​C and HZ. Inverse weighted variance (IVW) and weighted median methods showed that MCI had a protective effect on CP (IVW: β=-1.229, P = 0.010, odds ratio [OR] = 0.293, 95% confidence interval [CI] = 0.114–0.749; Weighted median: β=-1.328, P = 0.008, OR = 0.265, 95%CI = 0.100-0.705). However, MR-Egger analysis suggested no causal association (β=-1.642, P = 0.103, OR = 0.194, 95%CI = 0.048–0.774). The greater precision of weighted median estimator and IVW suggest our results may support a potential causal association between cysteine ​​C and HZ . Conclusion The MR analysis demonstrated that cysteine ​​C has a protective effect on HZ.