Background. Use of Hydroxychloroquine with or without Azithromycin is repurposed in SARS-CoV-2 in the absence of definitive treatment. Objective. To evaluate the association between the use of Hydroxychloroquine and Azithromycin when given alone or in combination on clinical outcomes and adverse drug reactions among lab confirmed SARS CoV-2 positive patients admitted in a COVID tertiary care hospital of a University Medical college. Methods. a retrospective observational comparative study was conducted. COVID-19 positive patients admitted in study hospital for management of COVID-19 were enrolled into the study. The patients were categorized into 4 treatment groups based on having received the following treatment during hospitalization: (A) Hydroxychloroquine with Azithromycin, (B) Hydroxychloroquine without Azithromycin (Hydroxychloroquine alone), (C) Azithromycin alone, and (D) Neither drug, defined as no receipt of either Hydroxychloroquine or Azithromycin in the record; other medications may have been dispensed. Results. 800 patients were enrolled. Mean±Standard deviation of duration of hospital stay (in days) for study Group A was 11.37±7.11, for Group B was 8.37±4.77, for Group C was 18.22 ± 5.69 and for Group D was 6.12±2.97. Mortality in Group A was 29.74%, Group B – 33.16%, Group C – 0% and in Group D – 1.32%. Conclusion. Among hospitalized patients with COVID-19 treatment, Group C was associated with good clinical outcome. However, the interpretation of these findings may be limited by the observational design.

Objective: The objective of the current study is to evaluate knowledge, attitude, and perception of Indian Population about generic versus Branded Medicines. Methods: It was a cross-sectional prospective web-based questionnaire study. We used an application name Google form and link (https://forms.gle/ RJA6XvPeJy6TXNzN9) was created. Total 537 participants took part in our study. Nineteen questions related to knowledge, attitude, and perception about generic versus branded medicines were asked in the questionnaire. Results: In our study, 78.6% participants had heard about generic medicines. About 66.2% agreed that they understand the difference between both the medicines. About 74.5% knew that there is price difference in both the medicines. According to only 22.1% of our study participants’ doctors preferred generic medicines and 37.7% thought that chemists preferred to sell generic medicines than branded ones. About 40.4% knew that generic medicines are promoted by Indian government but surprisingly, 63.3% said that they are unaware of any government rules regarding this. About 44.9% did not know about the type of drugs on their prescription. About 54.8% preferred to buy generic medicines but interesting fact is that 74.3% had not asked their doctors to prescribe generic medicines but 41.7% believed that generic medicines should be promoted. Conclusion: Results of our study revealed that poor knowledge, negative attitude, and false perception regarding generic medicines are the main hindrance of sits acceptance by general population.

Background. On March 24, 2020, a nationwide Lockdown for 21 days was ordered by the Government of India which was then extended till May 31, 2020. Researchers have predicted lockdown is a necessary step to prevent COVID-19 spread. However, others have also stated that it could cause serious damage to the economic, mental, social, and physical well-being of the people. Objective. The aim of the study is to evaluate the impact of lockdown on the quality of life and well-being of the Indians. Methods. It is a cross sectional prospective web-based questionnaire study. A link (https://forms.gle/pX25VuahP5NxT88QA) was created. Total 426 responses were received via that link and the data was included in the statistical analysis. Results. Our study revealed that during the lockdown 61.5% of the respondents were performing physical activities lesser than before. More than half responded they had a reduced financial satisfaction. Most answers on emotional well-being and social-family wellbeing were also positive, but some responses showed disturbing too, like 22% felt anxious and nervous over half of the days. It was found in the study that physical, financial, emotional, mental, social and family wellbeing were disturbed during the lockdown and quality of life was also hampered. Conclusion. Though, may be Nationwide Lockdown was the most required action at that point of time to prevent virus spread, but our study revealed that uncertainty regarding its cure and management guidelines like lockdown and social distancing has badly affected quality of life and wellbeing of the population.

antiresorptive agents against each other didn't evidence a statistically significant difference. ConClusions: The results of this MTC can suggest that Risedronate, compared to placebo, is expected to provide the highest rate of reduction in NVF in women affected by postmenopausal OP. However, the mixed treatment comparisons among alendronate, risedronate, ibandronate, zolendronate and denosumab did not evidence a statistically significant difference.