The photon counting efficiency of various CCD based cameras was studied as a function of xray energy and exposure. A pair of Spectral Instruments Model 800 CCD cameras fitted with 16 µm thick back-illuminated CCDs were calibrated at low x-ray energy using two well established histogram methods, a standard pixel for pixel histogram and the single pixel event histogram method. In addition, two new thick substrate CCDs were evaluated for use at high energy. One was a commercially available Princeton Instruments LCX1300 deep depletion CCD camera while the other was a custom designed 650 µm thick partially depleted CCD fitted to a SI 800 camera body. It is shown that at high x-ray energy, only a pixel-summing algorithm was able to derive spectral data due to the spreading of x-ray events over many pixels in the thicker substrate CCDs. This paper will describe the different algorithms used to extract spectra and the absolute detection efficiencies using these algorithms. These detectors will be very useful to detect high-energy x-ray photons from high-intensity short pulse laser interactions.