The present study aimed to evaluate the dietary influence of nano-selenium and nano-curcumin on lipid profile, immune status and growth performance in Ven-Cobb broiler chickens. A total of 360 broiler chicks were divided into four groups and each group comprised 90 chicks. Chickens kept in group I was fed with a broiler basal diet and it served as the control group. While chickens kept in groups II, III and IV were fed with nano-Se (0.3 mg/kg diet), nano-curcumin (200 mg/kg diet) and combination (0.15 + 100 mg/kg diet) of both, respectively. Immune status of the birds was determined by measuring serum antibody titre against Newcastle Disease and Infectious Bursal Disease (IBD) and lipid profile also estimated on days 21st, 28th, 35th and 42nd. Significantly (p < 0.05) higher levels of serum high-density lipoprotein cholesterol, Ab titre against IBD and relative weights of spleen and thymus were recorded in Group II, III and IV compared to the control group. Significantly (p < 0.05) lower serum cholesterol levels were observed in Group III and IV compared to Group I. Significant (p < 0.05) improvement in body weight and feed conversion ratio were recorded in Group II and IV compared to Group I on sixth week. It is concluded that supplementation of Nano-Selenium at 0.15 mg/kg diet and nano-curcumin at 100 mg/kg diet in broiler chicken feed improves the production performance and exerts a hypo-lipidemic effect.