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Background: This study is being conducted to find out whether coronavirus disease 2019 (COVID-19) is associated with an increased incidence of MSAF in COVID-positive pregnant women. Finding implications for operative delivery and perinatal outcome. The evidence will help in managing COVID-positive women in pregnancy. Methods: This prospective observational study was conducted from July 1, 2020 to October 20, 2020 at Rajarajeswari Medical College and Hospital, Bangalore. A total 38 newborns born to SARS-COVID-19 infected mothers were included. Data collected from pregnant women, patient records, birth registries, operating room/delivery room records and NICU registries. Results: The clinical characteristics of 38 mothers and their newborns were analyzed. The mode of delivery was normal vaginal delivery (NVD) in most (N=21) cases. All newborns tested negative for SARS-CoV-2. 18 babies required only routine newborn care, and 20 babies required neonatal intensive care unit (NICU) admission at birth for management of meconium-stained amniotic fluid (MSAF)(11pregnancies), prematurity (3 cases), dyspnea (6 cases), stage 2/3 hypoxic ischemic encephalopathy (HIE) (2 cases), and Jaundice (9 cases). 18 of 38 stable babies held mother's side and breastfeeding started, with no signs and symptoms attributed to SARS-CoV-2. Conclusions: In our study, the prevalence of MSAF is higher (28%) in COVID-19 Positive mothers, resulting in low APGAR scores and poor perinatal outcomes. Vigilant intrapartum care is recommended to reduce the risk of poor neonatal outcomes. No newborns developed signs and symptoms of SARS-CoV-2 infection during rooming-in, breastfeeding and during admissions at neonatal intensive care unit (NICU).

Background: Among the premature infants, WINROP (weight, insulin like growth factor 1, neonatal retinopathy of prematurity), a web- based retinopathy of prematurity (ROP) risk algorithm, uses postnatal weight gain in predicting the risk of severe ROP. This retrospective study assess the sensitivity and specificity of WINROP algorithm to predict proliferative ROP (type 1, type 2).Methods: This was a tertiary hospital based retrospective study conducted in level 3 - NICU from February -November 2018. The data was entered in WINROP website. 45 neonates enrolled in the study, were classified as either alarm given (increased risk of severe ROP) or not given (no risk of severe ROP/ no ROP). Timing of alarm was also noted.Result: 10 neonates (22%) had severe ROP requiring treatment. The mean gestational age was 30 weeks and mean birth weight was 1275 grams. In this study, sensitivity to WINROP online system was found to be 90%, specificity of 48.6%, positive predictive value of 33.3% and negative predictive value of 94.4%. The median time from alarm to treatment was 6 weeks (3-8 weeks).Conclusion: WINROP algorithm has a good sensitivity in detection of treatable ROP.