In this paper, we introduced the integration of well-known TD tools that have been applied in many fields including product development, project management, many engineering disciplines, design of the organization, sustainable development, social issues, environmental issues, and others across many industries including automotive, aerospace, telecom, semiconductor, defense, transportation, energy, healthcare, agriculture, and more. The main objective of this paper is to introduce a new transdisciplinary (TD) engineering-based integrated approach to designing and developing a 3D silicone printing machine (SPM). Factors in designing and developing 3D SPM were simplified by considering the main factors affecting the performance of 3D SPM. Results are discussed and the modular 3D silicone printing machine design was presented. Using the Axiomatic Design (AD) tool, components of each module were identified to satisfy the functional requirements of the 3D SPM. Six TD-integrated tools were used to design the 3D SPM in this research. They are Quality Function Deployment (QFD), House of Quality (HOQ), TRIZ, AD, Interpretive Structural Modeling (ISM), and Design Structure Matrix (DSM).