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Synthesis and Properties of 2-(4-Substituted)butyl Derivatives of Some 2,3-Dihydro-1,3-dioxo-1H-pyrrolo [3,4-c]pyridines.-All the title compounds (V) show strong analgesic activity, suppress spontaneous locomotor activity and prolonged barbiturate sleep. Moreover, the majority of compounds (V) significantly decreases systolic and diastolic blood pressure. -(SLADOWSKA, H.; SZKATULA, D.; FILIPEK, B.; MACIAG, D.; SAPA, J.; ZYGMUNT, M.; Pharmazie 56 (2001) 2, 133-138; Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; EN)

Pyrazine derivativesPyrazine derivatives R 0550 Investigations on the Synthesis and Pharmacological Properties of 4-Alkoxy-2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl]-6-methyl-1H-pyrrolo[3,4-c]pyri-dine-1,3(2H)-diones. -All the title compounds (III) exhibit potent analgesic activity which is superior to that of acetylsalicylic acid in two different tests. Furthermore, most of the imides suppress significantly spontaneous locomotor activity in mice. -(SLADOWSKA*, H.; FILIPEK, B.; SZKATULA, D.; SABINIARZ, A.; KARDASZ, M.; POTOCZEK, J.; SIEKLUCKA-DZIUBA, M.; RAJTAR, G.; KLEINROK, Z.; LIS, T.; Farmaco 57 (2002) 11, 897-908; Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; Eng.) -M. Kowall 10-162

Investigations on the Synthesis and Properties of N-Aryl(heteroaryl) piperazinylalkyl Derivatives of Imide of 6-Methyl-2-(1-piperidino)-3,4-pyridinedicarboxylic Acid.-In the search for new chemical compounds with analgesic and antidepressant activities the title compounds are synthesized and tested. -(SLADOWSKA, H.; SIEKLUCKA-DZIUBA, M.; MISZTAL, M.; KLEINROK, Z.; Farmaco, Ed. Sci. 49 (1994) 7-8, 493-498; Dep. Chem. Drugs, Sch. Med., PL-50-137 Wroclaw, Pol.; EN)