10.30699/jambs.28.130.284 Background & Objective: Behçet's disease (BD) is a multisystemic inflammatory vascular disorder with an autoimmune background. It is a genetic disease which can be affected by environmental factors. Behçet's disease may involve different organs like urogenital system, skin, eyes, and gastrointestinal system. The prevalence of the disease varies considering the geographic area and genetic predisposition. This study aims to evaluate some clinical features of mucocutaneous lesions of BD. Materials & Methods: This cross-sectional study was done on 43 patients with BD (24 men, 19 women). Age, sex, disease duration, and history of receiving medication were investigated. The self-reported questionnaire was completed by participants. Skin manifestations and genital and ocular involvements were also documented. Results: Male to female ratio was measured 1.26:1. Oral aphthous commonly localized on the lips. Ocular involvements and skin lesions prevalence percentages were 76% and 48%, respectively. There was a statically significant correlation between ocular lesions and age. Skin lesions and the frequency of oral aphthous per year had a significant relationship. There also was a significant relationship between the incidence of ocular lesions and skin lesions. Conclusion: Oral aphthous, the most popular manifestation of BD, is the hallmark of diagnosis. Thus, patients with oral aphthous require close surveillance for other manifestations of BD for timely diagnosis and reference to a rheumatologist.