Objective: To evaluate the relationship between the genetic polymorphism of prostate stem cell antigen (PSCA) and the risk of advanced precancerous gastric lesions including intestinal metaplasia(IM) and dysplasia(Dys), a population-based study was conducted in Linqu County, a high-risk area of gastric cancer (GC) in China.Methods: The prevalence of gastric lesions including superficial gastritis(SG), chronic atrophic gastritis(CAG), IM and Dys was determined by histopathologic examination. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The effects of PSCA genetic variant on the risks of IM and Dys were calculated by unconditional logistic regression.Results: Multivariate analysis revealed subjects carrying PSCA rs2294008 CT/TT genotype were associated with an increased risk of IM (OR=1.38, 95% CI=1.11-1.71) and Dys (OR=1.75, 95% CI=1.36-2.26), especially for subjects with H.pylori infection (IM: OR=1.34, 95% CI=1.05-1.71; Dys: OR=1.82, 95% CI=1.37-2.42). Furthermore, H. pylori infection and PSCA rs2294008 CT/TT genotype were observed to jointly elevate the risk of IM (OR=3.32, 95% CI=2.33-4.71) and Dys (OR=4.58, 95% CI=2.99-7.04).Conclusion: This study suggested that PSCA rs2294008 might have an impact on the risk of IM or Dys among the high risk population of GC.

Mu et al.: Respiratory Failure in Glufosinate PoisoningAcute glufosinate ammonium poisoning can cause neurological complications and respiratory failure, which are usually delayed and difficult to predict. Serum ammonia level might be an indicator of severe glufosinate poisoning, but it has not been confirmed. We aimed to investigate the potential predictors of respiratory failure after glufosinate poisoning. We conducted a retrospective review of 21 cases of glufosinate poisoning between 2010 and 2019. Patients were assigned to intubated due to respiratory failure and non-intubated groups. The following characteristics were compared between these two groups; age, sex and period from poisoning to hospital arrival, vital signs, Glasgow coma scale, laboratory parameters and electrocardiogram measurements. Furthermore, the outcomes of morbidity and mortality were analyzed. Totally, 12 cases were be intubated and the other 9 were not intubated. Leukocytosis, hyperglycemia, increased serum creatinine, peak ammonia level and decreased Glasgow coma scale score found at emergency visits were significantly different between these two groups. The white blood cell count (median: 9100 vs. 15 785, p=0.046) and serum creatinine (median: 0.88 vs. 1.20, p=0.019) and blood sugar (median: 114.0 vs. 138.5, p=0.032) levels were higher and the initial Glasgow coma scale score was lower in the intubated group than in the non-intubated group (median: 15 vs. 13, p=0.030). Moreover, six patients who presented with a decreased Glasgow coma scale score and an increased ammonia level developed respiratory failure. In cases of glufosinate poisoning, leukocytosis, hyperglycemia, impaired renal function and decreased Glasgow coma scale score initially can use to predict respiratory failure. Moreover, conscious change combined with an early increase in serum ammonia level implied that, intensive monitoring should be required to prevent lethal complications from delayed onset of respiratory failure.