The methylnitrone of 3-methyl-1,4-dioxidoquinoxaline-2-carboxaldehyde (1) has been exceptional antibacterial activity in vivo. Derivatives of 3-hydroxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde and 3-acetoxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as I.

A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.

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Aus den 2‐Methyl‐chinoxalin‐di‐Näoxiden (I) entstehen mit Selendioxid die Formyl‐Verbindungen (II), die mit Hydroxylaminen‐(III) zu den Nitronen (IV) führen.

Benzofuroxan (I) reagiert mit 4‐Hydroxy‐2‐butanon (II) in Gegenwart von Ammoniak und Methanol zum Chinoxalin‐di‐N‐oxid (IIIa), das zu (IIIb) acetyliert wird.