No abstract

Background: Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients. Methods: This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/ mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm 2 ). The primary outcome was the decline in periodontal probing depth (PD) at 6 months. The secondary outcomes were peri-implant plaque index (PLI), sulcular bleeding index (SBI), and clinical attachment loss (CAL). Results: PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3-and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls). Conclusion: PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.Abbreviations: AE = adverse event; CAL = clinical attachment loss; DB = distobuccal; PD = pocket depth; PDT = Photodynamic therapy; PLI = peri-implant plaque index; SBI = sulcular bleeding index.

Purpose To report surgical outcomes of microcatheter-assisted trabeculotomy following failed angle surgeries, and compare those with no previous angle surgery, in primary congenital glaucoma (PCG). Methods The early postoperative (12 months) results of 42 eyes of 36 patients who underwent microcatheter-assisted trabeculotomy by single surgeon for PCG were retrospectively analyzed. Group 1, 20 eyes of 16 patients, had no previous angle surgery. Group 2, 22 eyes of 20 patients, had one or two previous failed angle surgeries. Success was defined as an intraocular pressure (IOP) o21 mm Hg with at least a 30% reduction from preoperative IOP with (qualified success) or without (complete success) the use of antiglaucoma medication. Results Mean IOP decreased from 31.5 ± 7.2 mm Hg on 3 (median, range: 1-5) medications in Group 1 and 34.6 ± 7.3 mm Hg on 3 (median, range: 1-4) medications in Group 2 preoperatively to 15.6 ± 3.1 mm Hg on 0 (median, range: 0-4) medications in Group 1 and 16.0 ± 4.6 mm Hg on 0 (median, range: 0-2) medications in Group 2 postoperatively at 12 months (both Po0.001), respectively. The mean percentage of IOP reduction from preoperative to last postoperative visit was 46.0 ± 20.1% in Group 1 and 45.5 ± 25.0% in Group 2, P = 0.947. Qualified and complete successes were comparable between Group 1 and Group 2 (qualified success: 90.0% vs 77.3%, P = 0.294; complete success: 78.9% vs 77.3%, P = 0.853). Complications were minimal. Conclusions Microcatheter-assisted trabeculotomy achieved significant pressurelowering effects with a reduction in medication use in PCG, and it represents a reasonable choice of initial and repeat surgical treatment for PCG.