Summary Background Pioneering effort has been made to facilitate the recognition of pathology in malignancies based on whole‐slide images (WSIs) through deep learning approaches. It remains unclear whether we can accurately detect and locate basal cell carcinoma (BCC) using smartphone‐captured images. Objectives To develop deep neural network frameworks for accurate BCC recognition and segmentation based on smartphone‐captured microscopic ocular images (MOIs). Methods We collected a total of 8046 MOIs, 6610 of which had binary classification labels and the other 1436 had pixelwise annotations. Meanwhile, 128 WSIs were collected for comparison. Two deep learning frameworks were created. The ‘cascade’ framework had a classification model for identifying hard cases (images with low prediction confidence) and a segmentation model for further in‐depth analysis of the hard cases. The ‘segmentation’ framework directly segmented and classified all images. Sensitivity, specificity and area under the curve (AUC) were used to evaluate the overall performance of BCC recognition. Results The MOI‐ and WSI‐based models achieved comparable AUCs around 0·95. The ‘cascade’ framework achieved 0·93 sensitivity and 0·91 specificity. The ‘segmentation’ framework was more accurate but required more computational resources, achieving 0·97 sensitivity, 0·94 specificity and 0·987 AUC. The runtime of the ‘segmentation’ framework was 15·3 ± 3·9 s per image, whereas the ‘cascade’ framework took 4·1 ± 1·4 s. Additionally, the ‘segmentation’ framework achieved 0·863 mean intersection over union. Conclusions Based on the accessible MOIs via smartphone photography, we developed two deep learning frameworks for recognizing BCC pathology with high sensitivity and specificity. This work opens a new avenue for automatic BCC diagnosis in different clinical scenarios. What's already known about this topic? The diagnosis of basal cell carcinoma (BCC) is labour intensive due to the large number of images to be examined, especially when consecutive slide reading is needed in Mohs surgery. Deep learning approaches have demonstrated promising results on pathological image‐related diagnostic tasks. Previous studies have focused on whole‐slide images (WSIs) and leveraged classification on image patches for detecting and localizing breast cancer metastases. What does this study add? Instead of WSIs, microscopic ocular images (MOIs) photographed from microscope eyepieces using smartphone cameras were used to develop neural network models for recognizing BCC automatically. The MOI‐ and WSI‐based models achieved comparable areas under the curve around 0·95. Two deep learning frameworks for recognizing BCC pathology were developed with high sensitivity and specificity. Recognizing BCC through a smartphone could be considered a future clinical choice.
Summary Basal cell carcinoma (BCC) is the most common skin cancer with a rapidly rising incidence. The diagnosis of BCC requires careful inspection of microscopic skin images, which is labour‐intensive due to the large number of images to be analyzed. Computer‐aided diagnosis of diseases has been developed to help the analysis of microscopic images in pathology (which is the study and diagnosis of disease by examining tissue that has been removed.) In particular, deep learning approaches, which are ways in which a machine can ‘learn’ to perform a task, are able to identify and capture patterns in images and have shown significantly improved performance on pathological image‐related tasks. In this study, from China, the authors aimed to develop deep learning frameworks for automatic recognition of BCC based on smartphone‐captured microscopic ocular images (MOI) instead of whole slide images (WSIs). MOIs are photographed from microscope eyepieces using smartphone cameras. A total of 8046 MOIs and 128 WSIs were collected and used to build models. Two deep learning frameworks for recognizing BCC pathologically were developed with high sensitivity and specificity (meaning accuracy). Compared with the model trained on WSI, recognizing BCC through smartphones could be considered as a future clinical choice. This is a summary of the study: Recognizing basal cell carcinoma on smartphone‐captured digital histopathology images with a deep neural network
The accurate prediction of vehicle speed is crucial for the energy management of vehicles. The existing vehicle speed prediction (VSP) methods mainly focus on road vehicles and rarely on off-road vehicles. In this paper, a double-layer VSP method based on backpropagation neural network (BPNN) and long short-term memory (LSTM) for off-road vehicles is proposed. First of all, considering the motion characteristics of off-road vehicles, the VSP problem is established and the relationship between the variables in the problem is carefully analyzed. Then, the double-layer VSP framework is presented, which consists of speed prediction and information update layers. The speed prediction layer established by using LSTM is to predict vehicle speed in the horizon, and the information update layer built by BPNN is to update the prediction information. Finally, with the help of mining truck and loader operation scenarios, the proposed VSP method is compared with the analytical method, BPNN prediction method, and recurrent neural network (RNN) prediction method in terms of speed prediction accuracy. The results show that, under the premise of ensuring the real-time prediction performance, the average prediction error of the proposed BPNN-LSTM prediction method under two operation scenarios reduces by 48.14%, 35.82% and 30.09% compared with the other three methods, respectively. The proposed speed prediction method provides a new solution for predicting the speed of off-road vehicles, effectively improving the speed prediction accuracy.
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