2) have been synthesized under hydrothermal conditions. In compound 1, 2D {[Gd 2 (CO 3 ) 2 ] 2+ } n sheets are connected by [Cu(pydc) 2 ] 2bridges, which give rise to the formation of a sandwichlike framework. Compound 2 exhibits a 3D framework constructed by Gd 4 clusters, Co 2 subunits, and pydc spacers. The solid-state dc magnetic measurements reveal antiferromagnetic behaviors of 1 and 2 in both compounds.
Superoxide dismutase (SOD) is one of the major antioxidants in vivo and is expected to play critical roles on the defense
against reactive oxygen species (ROS)-mediated damages, such as ionizing
radiation damages. Herein, inspired by the function and structure
of natural SODs and cerium oxide nanozymes, two monovalent cerium-based
metal organic frameworks (Ce-MOFs), CeIIIBTC and CeIVBTC, were designed for superoxide radical (O2
•–) elimination and ionizing radiation protection.
These two Ce-MOFs selectively scavenge O2
•– and are excellent SOD mimics. Like natural SODs and cerium oxide
nanozymes, the SOD-like catalytic mechanism of Ce-MOFs involves a
cycle between Ce(IV) and Ce(III). Furthermore, by constructing monovalent
Ce-MOFs, we found that high-valent CeIVBTC are more effective
SOD-like nanozymes compared to CeIIIBTC. With smaller size,
better monodispersity, and more effective SOD-like activity, CeIVBTC nanozymes were further applied for ionizing radiation
protection. Both in vitro and in vivo results demonstrated that CeIVBTC nanozymes could efficiently
scavenge ROS, prevent cells from γ-ray radiation-induced cell
viability decrease and DNA damages, and improve the survival rate
of irradiated mice by recovering the bone marrow DNA damage and alleviating
oxidative stress of tissues. The protective effect and good biocompatibility
of CeIVBTC nanozymes will enable the development of Ce-MOFs-based
radioprotectants and facilitate treatment of other ROS-related diseases.
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