The assessment of flash flood hazards in the coastal zone of Ras Ghareb City (RGC), Red Sea, Egypt, was accomplished through the use of GIS tools and the spatial multi-criteria approach. The presented work aims to assess, integrate, and generate potential flash flood hazard maps. The analytic hierarchy process was utilized to calculate weights of hazard and vulnerability of flash flood controlling factors and their parameters such as topographical, geological, and hydrological factors. In addition, the risk degree of each specific basin and its sub-basins is estimated by combining standardized parameter values. Despite its location in an arid region, the basin may receive a large amount of rainwater, which can cause flash floods at the basin's outlet. Recently, flash flooding took place in the coastal region of RGC in October 2016 and September 2020, resulting in the loss of many human lives and catastrophic effects on local infrastructure and surrounding environments. According to reports from Hurghada, Red Sea Governorate, the RGC experienced exceptional flooding that exceeded 120 million cubic meters as a result of 51 mm of rainfall. Based on the remote sensing satellite data such as Aster Digital Elevation Model (GDEM) and the GIS tools, the basin and sub-basin drainage patterns were delineated and compared with reference topographical map sheets of a scale of 1: 50,000. The sub-basins have been isolated and morphometrically studied to determine vulnerability to flash flooding. In addition, the flash flood threat model was developed using geoprocessing tools provided by ArcGIS software to incorporate all contributing factors spatially. The flash flood risk in the Ras Ghareb (RG) basins and their sub-basins has been identified and classified into three classes (high, medium, and low hazard degree). High and moderate flood-risk basins require comprehensive studies to introduce measures to protect certain areas from flood danger. Finally, the GIS and the spatial multi-criteria analyses were effective ways to carry out a flash flood management system in order to support the decision-makers by recommendations to conserve and mitigate the possible flash flood hazards in the study areas.