MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53-linked miRNAs, NOTCH-related miRNAs, miRNA-15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.

Background: Nowadays open meniscal repair approach is completely replaced by arthroscopic meniscal repair. Objectives: The current study aimed at assessing the results of arthroscopic meniscal repair using the outside-in technique. Methods: Patients diagnosed with meniscal tearing from 2008 to 2014 fulfilling the inclusion criteria were entered to the current cohort study. Outcomes of arthroscopic meniscal repair were assessed by 2 known questionnaires, IKDC (international knee documentation committee) and KOOS (knee injury and osteoarthritis outcome score), as well as magnetic resonance imaging (MRI) of knee.

Background: Despite the advances in the methods of treating femoral neck fractures, treating some types of these fractures is still challenging. Therefore, understanding these fractures, their treatments, and the ways to control their complications are necessary for the orthopedists.  Objectives: In this study, we evaluate patients with acute femoral neck fractures with respect to the type of fractures and complications. Methods: In a 4-year cross-sectional study, the patients with acute femoral neck fractures who were admitted to Rasoul Akram Hospital were selected. Anatomical features and the type of fracture were determined by using plain radiography and CT scan. Fractures were classified according to the Garden classification. The patients were also evaluated for any postoperative complications for at least 6 months. Results: A total of 124 patients were enrolled. The Mean±SD age of the patients was 64.9±12.7 years and 87 (74.4%) were male. Based on the Garden classification, 7 fractures (5.9%) belonged to type I, 10 fractures (8.5%) to type II, 48 fractures (41%) to type III, and 52 fractures (44.4%) to type IV. Avascular necrosis in 28 cases (23.9%), non-union in 14 cases (12%), and claudication and pain in 35 cases (29.9%) were noted. The mean age of patients was different between fracture groups (P=0.01).  Conclusion: Our results showed that most of the patients with femoral neck fractures admitted to Rasoul Akram Hospital were associated with displacement. In this study, the most common complications were pain and claudication, avascular necrosis of the femoral head, and nonunion. In sum, further displacement of the fracture will result in more complications.

Introduction: Ankle dislocations are a group of injuries requiring immediate orthopedic interventions to avoid subsequent neurovascular complications and impairments. In most cases, they are associated with a malleolar fracture in the ankle. However, in the sporadic cases, especially the ones due to high-energy traumas, ankle dislocations are not associated with malleolar fractures and are referred to as "pure ankle dislocations". Case Presentation: Here, we report a rare case of pure ankle dislocation in a 38-year-old female athlete with no previously established predisposing risk factors. The patient was referred to our emergency department following a catastrophic fall down during exercise, resulting in severe ankle pain and deformity. The patient was treated with urgent reduction of the displacement and 6 weeks of immobilization by casting followed by intensive physiotherapy. Conclusion: At the end of the 3-month follow-up, no symptoms of instability were observed, and the patient could walk normally; at the 6-month follow-up, the patient could perform her sport activates similar to the initial level.