Psoriasis is a common chronic skin disease, characterized by sharply demarcated, erythematous, scaly plaques. Psoriasis is supposed to be initiated by interplay between genetic, environmental, and immunological factors. C-reactive protein (CRP) has special importance for psoriasis due to its relation with cytokines which are responsible for skin inflammation.. In the present study determine the level of CRP by using highly sensitive method  (hs-CRP) with a detection limit 0.25mg/L and its correlation with severity of disease.

Material and methods: 50 Patients diagnosed as having psoriasis and 50 age and sex matched normal healthy control were studied after taking their consent. Psoriasis patients with Psoriasis Area Severity Index (PASI) less than 10 considered as mild Psoriasis and PASI greater than 10 considered as moderate to severe Psoriasis. blood sample was collected under aseptic precautions in plain vacutainer for  hsCRP estimation . hsCRP estimation done by latex  turbidimetric method.

Results: The present study found significant correlation between hsCRP and PASI ( p < 0.0001). Mean value of hsCRP in PASI<10 (mild psoriasis ) is 1.34 mg/L± 1.06 while Mean value of hsCRP with PASI >10 ( moderate to severe psoriasis ) is 6.26 ± 3.84   mg/L.

Conclusion: The finding of present study suggest that Psoriasis patients with moderate to severe psoriasis (PASI > 10) have higher mean Serum hsCRP level than patient mild psoriasis (PASI <10) and controls. Serum hsCRP level correlate significantly with Psoriasis Area Severity Index (PASI) and hsCRP level can be used as marker for assessing severity of disease.

BackgroundGlycation of serum proteins has been proposed as an important mechanism of complications of diabetes but whether there are differences in glycation of different serum proteins and whether it has any correlation with development of microvascular complications has not been studied in depth. This study aimed to assess level of serum fructosamine, glycated albumin and glycated β-lipoprotein in type 2 diabetes mellitus patients with and without microvascular complications and to find out their correlation with diabetes complications.MethodsCase–control study involving 150 individuals at a tertiary care hospital in western India. Fifty participants were healthy controls (group 1), 50 were type 2 diabetes patients without any evident microvascular complication (group 2) and 50 were type 2 diabetes patients with one or more microvascular complications (group 3). Serum fructosamine, FBS, PP2BS and other biochemical parameters were measured. Glycated albumin and glycated β-lipoprotein were measured by agarose gel electrophoresis followed by NBT staining. Unpaired t-test was used to find out significance of difference between two groups and correlation coefficient to find out statistical correlation between two variables.ResultsType 2 diabetes patients with one or more microvascular complications had poor glycemic control as indicated by markers of short and mid-term glycemia. Differences between the groups for fructosamine, glycated albumin and glycated β-lipoprotein were significant (p < 0.001). Glycated albumin correlated with FBS, PP2BS and fructosamine in all diabetic patients (group 2 and 3) whereas glycated β-lipoprotein correlated with these parameters only in group 3 and it was markedly elevated in group 3.ConclusionSerum glycated β-lipoprotein was disproportionately elevated compared to fructosamine and glycated albumin in diabetes patients with microvascular complications (group 3) and it correlated with rest of glycemic markers only in this group. Glycated β-lipoprotein might help in identifying diabetic individuals at high future risk of developing microvascular complications.