A kidney stone is one of the diseases that people have a lot of suffered and faced very often. Its treatment is generally performed conservatively, medically, or surgically according to the characteristics of the patient and the stone. In this study, the structure of calcium oxalate kidney stone from urinary system stone diseases is examined and the methods used in the treatment of this stone today, the success in the treatment, the advantages and disadvantages of these methods were compared and researched acid effect on the structure of these stone. The calcium oxalate structure was synthesized in this study. The effect of acetic acid, acetic acid glacial, citric acid, lemon and hydrochloric acid on this structure was investigated. Then, the structure of the stone was determined by XRD, FT-IR and SEM methods. The CaC2O4 stone was synthesized and examined using spectroscopic methods. The X-ray diffraction pattern of all syntheses has a similar structure and has a calcium oxalate peak. It is compatible with the literature. In the FT-IR spectrum, a broad spectrum peak was observed in the region between 3700 and 2760 cm -1 for all studied syntheses. It reveals the COM structure for H6, and the COD structure for H1, H2, H3, and H4. The effects of other acids on synthetic calcium oxalate were compared by using SEM images. It was obtained where the dimensional distribution of the particles was uniform and smaller than the others for the H4 which citric acid was added. It was observed that the tendency to cluster in the particles was higher than the others in the synthesis by adding glacial acetic acid.