Cut-off values for initial left ventricular ejection fraction of >27% and left ventricular end-systolic diameter of < or =5.5 cm may predict recovery of left ventricle function.

condition, alcohol intake, drug abuse, or family history of preeclampsia made significant independent contribution in predicting cardiac output in the multiple regression model. The mean log MoM cardiac output was 0.000 [95% confidence interval (CI): À 0.0025 to 0.0025] in the unaffected group, 0.0261 (95% CI: 0.0065-0.0457) in the preeclampsia group, 0.0257 (95% CI: 0.0079-0.0435) in the PIH group, and -0.0085 (95% CI: À 0.0157 to À 0.0013) in the SGA group. In the patients with preeclampsia, log MoM cardiac output increased significantly with birth weight percentile (r = 0.346, P<0.001), with mean values of 0.0382 (95% CI: 0.0108-0.0656) in the preeclampsia group without SGA and 0.0111 (95% CI: À 0.0174 to 0.0396) in the preeclampsia group with SGA, respectively. Compared with the unaffected population, the mean log MoM cardiac output was higher in the preeclampsia group (P = 0.01), preeclampsia without SGA group (P = 0.008), and in the PIH group (P = 0.003). The statistic was lower in the SGA group (P = 0.03), and not significantly different in preeclampsia with SGA (P = 0.44). Significant prediction for SGA was provided by lower log MoM cardiac output [odds ratio (OR): 0.29; 95% CI: 0.09-0.92], smoking (OR: 3.1; 95% CI: 2.4-4.1), b-mimetic medication (OR: 2.9; 95% CI: 1.7-5.4), crown-rump length (OR: 0.97; 95% CI: 0.96-0.99), and ethic origin. Areas under receiver operating characteristics curves were 0.813, 0.830, 0.630, and 0.629 for all preeclampsia, preeclampsia without SGA, PIH, and SGA. For a 10% false-positive rate, the respective true positive rates were 43.4%, 52.2%, 23.3%, and 23.9%.Compared with values in women who go on to have uncomplicated pregnancies, maternal cardiac output, as measured by echocardiography at 11 to 13 weeks' gestation, is increased in pregnancies that go on to be complicated by preeclampsia. Cardiac output at 11 to 13 weeks is decreased in women who subsequently deliver SGA infants. These changes predate the clinical onset of both disorders.

A b s t r a c tBackground: Myocardial injury induced by catheter ablation (CA) for atrial fibrillation (AF) leads to elevated biomarker levels.Aim: This prospective study examined levels of myocardial injury biomarkers (creatinine kinase [CK], myocardial bound for CK [CK-MB], and troponin I [TnI]) and their impact on AF recurrence following two different ablation strategies, namely: cryoballoon ablation (CBA) and radiofrequency ablation (RFA). We also aimed to evaluate the relationship between AF recurrence after CA and other clinical, echocardiographic and procedural parameters. Methods:We enrolled 98 patients with AF, 21% of whom had persistent AF and 79% had paroxysmal AF. 58% of patients underwent CBA, and 42% underwent RFA. CK, CK-MB, and TnI levels were measured before and 6 h after the procedure. Patients had follow-up visits three, six, and nine months after the index procedure. Biomarker levels were compared between the patients with and without AF recurrence.Results: Post-ablation CK (postCK), post-ablation CK-MB (postCKMB), and post-ablation TnI (postTnI) levels were significantly high in the CBA and RFA groups (p < 0.001 for all). TnI elevation (DTnI) was correlated with age (p = 0.033) and median temperature reached during ablation (p < 0.005) in the CBA group, while it was correlated with application time in the RFA group (p < 0.001). Multivariate analysis in the CBA group revealed age and left atrium diameter as positive independent predictors (p = 0.029 and p = 0.046), and DTnI as a negative independent predictor for AF recurrence (p = 0.001). Elevated cardiac biomarkers were not associated with AF recurrence in the RFA group (p > 0.05). Conclusions:The levels of all cardiac biomarkers were elevated after CBA and RFA. Elevated TnI levels after CBA were independent negative predictors of AF recurrence. Measurement of TnI levels after CBA may be useful for the prediction of better clinical outcome.

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Transverse and longitudinal LA size, LA volume, fluoroscopy time, presence of persistent AF, RUPV size, and the number of RPV ostia are associated with AF recurrence following cryoballoon-based ablation. RUPV size and fluoroscopy time are predictors for recurrence.