Objectives: The purpose of study was to explore the correlation of advanced oxidation protein products (AOPP), which reflect the oxidation of protein and the oxidative stress status, and the activity of antioxidant enzyme of Paraoxonase (PON1), using its arylesterase activity in patients with thyrodisim. Methods: The study included 100 women with newly diagnosed thyrodisim were subdivided in two groups according to thyroid hormones levels: hyperthyroidism group (50 female patients, age range 18-60 years); and hypothyroidism group (50 female patients, age range 18-75 years). A control group (30 healthy females, age range 18–70 years) was also included for comparison. Demographic and clinical measurements for all participants were recorded which include: Body mass index (BMI), age, weight, height, lipid profile, vitamin D, thyroid hormones (TSH, T3, and T4, FT3, FT4), AOPP levels, and arylesterase activity. Results: The serum level of AOPP in hypothyroidism group (71.92±19.04 μmol/L) and in hyperthyroidism group (30.41±4.72 μmol/L) were significantly higher than controls (13.12±2.50 μmol/L) (P<0.05). In contrast, lower aryl esterase activity was found in hypothyroidism (5.03±0.50 U/L), and hyperthyroidism (3.64±0.40 U/L) when compared to control group (6.78±0.62 Ku/L) with significant values (P< 0.05). Conclusions: these results disclosed a significant role of protein oxidation in patients with hypothyroidism as well as the oxidative stress status.

Background: Neudesin is a peptide secreted in brain and adipose tissues that has neural and metabolic functions. Its role as regulator of energy expenditure leads to assumption that its level may be regulated depending on thyroid gland pathology.Objective: This study aimed to investigate serum neudesin levels in patients with thyroidism and to evaluate1 any possible relationship between plasma neudesin levels and thyroid hormone levels. Methods: The study included 100 women with newly diagnosed thyroidisim were subdivided into two groups: hyperthyroidism group (50 female patients with1 age ranged from 18 to 60 years) and hypothyroidism group (50 female patients with age ranged from 18 to 75 years). A control group (30 healthy females with age ranged from 18 to 70 years) was also included for comparison. Body mass index (BMI) was evaluated. Plasma glucose, lipid profile, triiodothyronine (T3), thyroxin (T4), free T3, free T4, thyroid stimulating hormone (TSH), and neudesin levels were evaluated in all participants using ELISA kit. Results: The hyperthyroidism group had significantly (p=0.001) higher serum neudesin concentrations (4.47 ± 2.28 ng/mL) than in hypothyroidism (1.15 ± 0.43 ng/mL) and control groups (1.06 ± 0.36 ng/mL). A correlation analysis1 applied to the whole study group revealed a positive correlation between serum neudesin concentration and T4 in patients with hypothyroidism. Conclusions: Due to the relation of increased1 levels of neudesin in hyperthyroidism, neudesin may1 be related with one of pathophysiologic pathways of thyroidism. Still, it is not certain that higher neudesin level is involved in the pathogenesis1 of thyroidism or as a result of the disorder.