Statement of problem:Occlusal veneer is considered an extra-coronal restoration with less invasive preparation. Yet there is a shortage of information as regards the wear behavior of materials from which occlusal veneers are manufactured and their opposing enamel. Purpose: Evaluate the wear of bonded occlusal veneers constructed from two dissimilar materials along with their opposing enamel following chewing simulation. Material and Methods: 16 table tops of two dissimilar materials "lithium disilicate and polymer infiltrated ceramics" were manufactured with a complete digital workflow. The occlusal veneers were bonded in accordance with the manufacturer's directions to their corresponding epoxy resin dies. 2-body wear test with 49 N of mastication force and 37,500 cycles was done and wear behavior was determined by substance loss and roughness changes. Results:The weight loss of Rosetta SM occlusal veneers was higher than Vita Enamic occlusal veneers p value <0.0001 however, the roughness of enamel opposing Vita Enamic was statistically higher than Rosetta SM after wear simulation test p-value =0.02. Conclusions: Rosetta SM occlusal veneers have better wear resistance than Vita Enamic occlusal veneers. However, the Rosetta SM occlusal veneers showed better influence on the enamel antagonists in comparison to Vita Enamic occlusal veneers after wear simulation.