Purpose Pregabalin exhibits potent anticonvulsant, analgesic, and anxiolytic activity in animal models. However, few studies have evaluated pregabalin's potential peripheral effects on neuropathic pain. The aim of this study was to evaluate the peripheral analgesic effects of pregabalin in a rat model of neuropathic pain. Methods Male Sprague-Dawley rats were prepared by ligating the left L5 and L6 spinal nerves to produce neuropathic pain. Sixty rats with neuropathic pain were randomly assigned to six groups. Normal saline (control) and pregabalin (10,20,30, and 50 mgÁkg -1 ) were administered to the plantar surface of the affected left hind paw. Pregabalin (50 mgÁkg -1 ) was administered into the unaffected contralateral paw in order to determine its systemic effect. Responses to mechanical, cold, and heat stimulation were recorded at 15,30, 60, 90, 120, 150, and 180 min after drug administration. Rotarod performance was measured to detect drug-induced side effects, including sedation and reduced motor coordination. Results Saline injected into the affected paw and a pregabalin dose of 50 mgÁkg -1 injected into the contralateral paw showed no differences for mechanical, cold, and heat allodynia. Administration of pregabalin to the affected left hind paw in the dose range of 10-50 mgÁkg -1 resulted in a dose-dependent increase in thresholds to mechanical, cold, and heat stimulation. Conclusion Peripherally administered pregabalin attenuates mechanical, cold, and heat allodynia in a rat model of neuropathic pain. RésuméObjectif La pre´gabaline de´montre une puissante activiteá nticonvulsivante, analge´sique et anxiolytique dans les mode`les animaux. Ne´anmoins, il n'existe que peu d'e´tudes ayant e´value´les effets pe´riphe´riques potentiels de la pre´gabaline sur la douleur neuropathique. L'objectif de cette e´tude e´tait d'examiner les effets analge´siques pe´riphe´riques de la pre´gabaline dans un mode`le de douleur neuropathique chez le rat. Méthode Des rats Sprague-Dawley maˆles ont e´teṕ re´pare´s en ligaturant les nerfs rachidiens L5 et L6 afin de cre´er une douleur neuropathique. Soixante rats souffrant de douleur neuropathique ont e´te´ale´atoirement re´partis en six groupes. Du se´rum physiologique (te´moin) et de la pre´gabaline (10, 20, 30, et 50 mgÁkg -1 ) ont e´te´administre´s a`la surface plantaire de la patte arrie`re gauche affecte´e. De la pre´gabaline (50 mgÁkg -1 ) a e´te´administre´e à la patte controlate´rale non affecte´e afin de de´terminer son effet syste´mique. Les re´actions aux stimulations me´caniques, au froid et a`la chaleur ont e´te´enregistre´es a1 5, 30, 60, 90, 120, 150 et 180 min apre`s l'administration du me´dicament. La performance au test de la tige tournante a e´te´mesure´e afin de de´pister les effets secondaires provoque´s par le me´dicament, notamment la se´dation et une re´duction de la coordination motrice.This article is accompanied by an editorial. Please see Can J Anesth 2010; 57(7).

BackgroundPrevious studies have shown that sugammadex resulted in the prolongation of prothrombin time and activated partial thromboplastin time. In this study, we aimed to investigate the in vitro effects of exogenous sugammadex on the coagulation variables of whole blood in healthy patients who underwent orthopedic surgery.MethodsThe effects of sugammadex on coagulations were assessed using thromboelastography (TEG) in kaolin-activated citrated blood samples taken from 14 healthy patients who underwent orthopedic surgery. The in vitro effects of three different concentrations of sugammadex (42, 193, and 301 μg mL− 1) on the TEG profiles were compared with those of the control (0 μg mL− 1). Previous studies indicated that these exogenous concentrations correspond to the approximate maximum plasma concentrations achieved after the administration of 4, 16, and 32 mg kg− 1 sugammadex to healthy subjects.ResultsIncreased sugammadex concentrations were significantly associated with reduced coagulation, as evidenced by increases in reaction time (r), coagulation time, and time to maximum rate of thrombus generation (TMRTG), and decreases in the angle, maximum amplitude, and maximum rate of thrombus generation. Compared with the control, the median percentage change (interquartile range) in the TEG values of the samples treated with the highest exogenous sugammadex concentration was the greatest for r, 53% (26, 67.3%), and TMRTG, 48% (26, 59%).ConclusionsThis in vitro study suggests that supratherapeutic doses of exogenous sugammadex might be associated with moderate hypocoagulation in the whole blood of healthy subjects.Trial registrationidentifier: UMIN000029081, registered 11 September 2017.

PurposeOpioids may affect changes in the corrected QT interval (QTc) during anesthetic induction. This study examine whether a single bolus of remifentanil would prolong QTc after laryngeal mask airway (LMA) insertion during sevoflurane induction.Materials and MethodsForty women of American Society of Anesthesiologists physical status 1 (ASA PS1) undergoing gynecological surgery were studied. All patients were induced using three vital capacity inhalation inductions with 5% sevoflurane. Two minutes after induction, the inspiratory concentration of sevoflurane was reduced to 2%. Using double-blinded randomization, patients were allocated into one of two groups, receiving either saline (placebo group, n = 20) or 0.25 µg.kg-1 remifentanil (remifentanil group, n = 20) over a period of thirty seconds. Sixty seconds later, LMA insertion was performed. Recordings were taken with a 12-lead electrocardiogram at baseline, 2 min after induction and 1 and 3 min after LMA insertion. QTc was calculated by Bazett's formula. The mean arterial pressure (MAP) and heart rate (HR) were also measured at each time point.ResultsThe QTc interval was significantly prolonged in the placebo group as compared to the remifentanil group at 1 min after LMA insertion (467.8 ± 16.5 vs. 442.7 ± 21.3 ms, p < 0.001). However, there was no significant difference in QTc at 3 min after LMA insertion between the two groups. MAP and HR were significantly higher in the placebo group (p < 0.001).ConclusionA single bolus of remifentanil is safe method to attenuate prolonged QTc associated with insertion of LMA.

The purpose of study was to evaluate the perioperative lung ultrasound findings of patients undergoing scoliosis correction. LUS examination was performed examined three 3 times for each patient: 20 min after starting mechanical ventilation of the lungs(preoperative), after surgery when the patient was placed in the supine position(postoperative), and 20 min after arrival in the post-anaesthesia care unit. Arterial blood gas analyses, mechanical ventilation parameters, peripheral oxygen saturation(SpO2) were also checked. Twenty-six patients completed the study. The changes of LUS score(20 min) was significantly negatively correlated with the partial pressure of arterial oxygen(PaO2)/fraction of inspired oxygen(FiO2) ratio change(P = 0.039, r = −0.40). The change in mean convex side LUS score was significantly greater than that of the concave side as determined by two-factor repeated measures analysis of variance(p = 0.001). Multiple regression analysis revealed perioperative LUS change was the significant factor related to the oxygen index change (p = 0.042). One case of pneumothorax was diagnosed and pleural thickening more than 5 mm was detected in 8 patients and five patients of those were diagnosed pleural effusion and performed thoracentesis after surgery. Postoperative increase of LUS score was related with deteriorating of oxygenation at one day after surgery, and it suggests that lung ultrasound allows prediction of postoperative hypoxia and facilitates the diagnosis of pulmonary complications at operation room in AIS patients.