Fiber optic interferometers to sense various physical parameters including temperature, strain, pressure, and refractive index have been widely investigated. They can be categorized into four types: Fabry-Perot, Mach-Zehnder, Michelson, and Sagnac. In this paper, each type of interferometric sensor is reviewed in terms of operating principles, fabrication methods, and application fields. Some specific examples of recently reported interferometeric sensor technologies are presented in detail to show their large potential in practical applications. Some of the simple to fabricate but exceedingly effective Fabry-Perot interferometers, implemented in both extrinsic and intrinsic structures, are discussed. Also, a wide variety of Mach-Zehnder and Michelson interferometric sensors based on photonic crystal fibers are introduced along with their remarkable sensing performances. Finally, the simultaneous multi-parameter sensing capability of a pair of long period fiber grating (LPG) is presented in two types of structures; one is the Mach-Zehnder interferometer formed in a double cladding fiber and the other is the highly sensitive Sagnac interferometer cascaded with an LPG pair.

Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 encodes multidrug resistanceassociated protein 6 (MRP6), which is expressed primarily in the liver and kidneys. Mechanisms producing ectopic mineralization as a result of these mutations remain unclear. To elucidate this complex disease, a transgenic mouse was generated by targeted ablation of the mouse Abcc6 gene. Abcc6 null mice were negative for Mrp6 expression in the liver, and complete necropsies revealed profound mineralization of several tissues, including skin, arterial blood vessels, and retina, while heterozygous animals were indistinguishable from the wild-type mice. Particularly striking was the mineralization of vibrissae, as confirmed by von Kossa and alizarin red stains. Electron microscopy revealed mineralization affecting both elastic structures and collagen fibers. Mineralization of vibrissae was noted as early as 5 weeks of age and was progressive with age in Abcc6 ؊/؊ mice but was not observed in Abcc6 ؉/؊ or Abcc6 ؉/؉ mice up to 2 years of age. A total body computerized tomography scan of Abcc6 ؊/؊ mice revealed mineralization in skin and subcutaneous tissue as well as in the kidneys. These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease.

We propose simple and compact methods for implementing all-fiber interferometers. The interference between the core and the cladding modes of a photonic crystal fiber (PCF) is utilized. To excite the cladding modes from the fundamental core mode of a PCF, a coupling point or region is formed by using two methods. One is fusion splicing two pieces of a PCF with a small lateral offset, and the other is partially collapsing the air-holes in a single piece of PCF. By making another coupling point at a different location along the fiber, the proposed all-PCF interferometer is implemented. The spectral response of the interferometer is investigated mainly in terms of its wavelength spectrum. The spatial frequency of the spectrum was proportional to the physical length of the interferometer and the difference between the modal group indices of involved waveguide modes. For the splicing type interferometer, only a single spatial frequency component was dominantly observed, while the collapsing type was associated with several components at a time. By analyzing the spatial frequency spectrum of the wavelength spectrum, the modal group index differences of the PCF were obtained from to . As potential applications of the all-PCF interferometer, strain sensing is experimentally demonstrated and ultra-high temperature sensing is proposed.

A miniature Fabry-Perot (FP) interferometric fiber-optic sensor suitable for high-temperature sensing is proposed and demonstrated. The sensor head consists of two FP cavities formed by fusion splicing a short hollow-core fiber and a piece of single-mode fiber at a photonic crystal fiber in series. The reflection spectra of an implemented sensor are measured at several temperatures and analyzed in the spatial frequency domain. The experiment shows that the thermal-optic effect of the cavity material is much more appreciable than its thermal expansion. The temperature measurements up to 1000 degrees C with a step of 50 degrees C confirm that it could be applicable as a high-temperature sensor.

Family caregivers of terminal cancer patients experience burdens, but caregiving also has positive consequences. This study has important implications for the development of bereavement interventions that aim to encourage positive outcomes and reduce negative outcomes for caregivers.