Current study was intended to investigate the cytotoxic potential of Bombax ceiba L.by executing a wide range of in vitro assays. Brine shrimp lethality assay showed that stem wood's chloroform (CH) extract was highly toxic (LC50 42.41 ± 3.40 µg/ml) followed by acetone : ethyl acetate (AC:EA) extract with LC50 value of 72.92 ± 4.41 µg/ml. n-Hexane (NH) extract of root wood part caused 70.95 ± 1.77% inhibition of THP-1 cell line at 20 μg/ml concentration (IC50 15 ± 0.56 µg/ml). NH and CH extracts of stem wood part showed promising results in protein kinase inhibitory assay with 21 ± 1.2 and 29 ± 1 mm bald ZOI (MIC= 50 µg/disc) respectively. The present findings revealed that CH and NH extracts of stem wood as well as root wood part as an enriched source of phytochemicals possessing cytotoxic potential.

Current study is intended to investigate the antimicrobial and antidiabetic potential of Bombax ceiba L. Antileishmanial potential was assessed via MTT colorimetric method while antifungal activities were found out through disc diffusion method. The antidiabetic potential was investigated by α-amylase inhibition assay. Considerable antifungal activity (in the range of 10-12 mm ZOI) was demonstrated by CH: M extracts of both flower and stem bark, and CH extract of root bark against A. niger Whereas M: EA, AC extracts of leaf, EA extract of stem bark, NH, CH:E, M:EA extracts of root bark and NH extract of root wood exhibited the antifungal potential (ZOI from 10-12 mm) against F. solani. The most potent α-amylase inhibitory activity was shown by EA extract of leaf part with 66.69 ± 0.95% inhibition (IC50 190 ± 4.5 µg/ml). Selected plant is a potential source of antileishmanial, antifungal and antidiabetic agents. This information can be further utilized for the purpose of bioactivity guided isolation of biologically active principles of B. ceiba L.

Aim: To evaluate the frequency of acute ischemic stroke in patients with type-II diabetes mellitus. Study Design: Descriptive Cross sectional Study Place & Duration of Study: The study was carried out at Department of Medicine, DHQ Teaching Hospital, Dera Ismail Khan for the period of 06 months from 06 Feb, 2018 to 06 Aug, 2018. Methodology: All patients admitted through OPD presented with type-II diabetes mellitus and having acute ischemic stroke after radiological confirmation using non-contrast enhanced CT scan brain with type-II diabetes (as per operational definitions above) were enrolled in study. Informed written consent was taken by the researcher with detailed history followed by detailed clinical examination and all patients who was give their consent to participate in the study was questioned about their medical history and was examined in detail for their neurological deficits. All the laboratory investigation was done from single hospital laboratory and all the radiological investigations were done from hospital radiology department. Results: As per frequencies and percentages for acute ischemic stroke, 215 (74.65%) patients were found having acute ischemic stroke. Conclusion: In this study, we concluded that there is a significant age difference between the diabetes-stroke co-morbid patient and non-diabetic stroke patient. Therefore, health education on preventive measures for type 2 DM, adequate regulation of blood pressure and blood sugar level through compliance to medical advice and medication, regular clinic attendance and periodic measurement of blood pressure and blood sugar level.