Background: Multiple advancements of endoscopic technology were designed to enhance the sensitivity and specificity of the diagnostic tools of bladder cancer; thus, we perform a meta-analysis to compare diagnostic performance between confocal laser endomicroscopy (CLE) and biopsy for detecting bladder cancer.Methods: We compared CLE’s accuracy in diagnosing bladder cancer reported by studies obtained from the electronic database MEDLINE, CENTRAL, and CINAHL, from May to June 2020. The pooled effect estimate was calculated employing the DerSimonian and Laird random-effects model. We only included moderate to high-quality studies, which had been assessed by the QUADAS-2 tool.Results: Eight studies were included in this review; five of those were good-quality studies. A total of 519 samples from 345 patients were included in the pooled effect estimate calculation. Pooled sensitivity and specificity of CLE in diagnosing bladder cancer were 90.2% (0.86, 0.93) and 78.1% (0.71, 0.85), respectively. The use of white-light cystoscopy (WLC) before CLE increased its specificity (56.8% versus 84.6%). Pooled sensitivity and specificity of CLE in predicting lowgrade lesion were 73% (0.66, 0.80) dan 83% (0.78, 0.87), respectively. Meanwhile, pooled sensitivity and specificity of CLE in predicting high-grade lesion were 73% (0.66, 0.78) and 79% (0.73, 0.83), respectively.Conclusions: CLE has good accuracy in distinguishing malignant and benign tumors. Grading tumors with this modality is also accurate. The use of probe CLE (pCLE), coupled with WLC, will increase its specificity.
Introduction: The introduction of laparoscopy in the field of urology has advanced surgery into a minimally invasive era, achieving better perioperative outcomes and lower incidence of complications. This study reports on the profile of laparoscopic ureterolithotomy performed in Persahabatan Hospital, Jakarta.Method: This retrospective study examined laparoscopic procedures done during the years 2016-2019. Demographic characteristics, surgical duration, length of stay, perioperative parameters, and antibiotics prescribed were recorded.Result: A total of 30 cases were reported. The gender ratio was 2:1 (male to female), with a mean age of 54.2 ± 9.9. Twenty-two (73.3%) had proximal ureteric stone. Surgical duration and length of stay had means of 197.4 ± 46.1 minutes and 3.6 ± 1.1 days, respectively. The mean blood loss, preoperative and postoperative hematocrit was 40.5 ± 27.8 mL, 36.14% ± 5.73 and 35.76% ± 5.71, respectively. Mean preoperative and postoperative hemoglobin was 12.27 g/dL ± 1.84 and 12.12 g/dL ± 1.89, respectively. The mean postoperative pain VAS score was 2.1 ± 0.8. The most prescribed antibiotics for the procedure were cefoperazone (53.33%).Conclusion: Considerably short duration of operations and hospital stay comparable with other study findings were reported. This study can be applied as baseline data for further research.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.