HAO472 has positive effects on TNBS-induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation and inhibiting the nuclear translocation of NF-κB p65 subunits.

Present modeling algorithm for large-sized revolving parts’ camber can not ensure the smoothness, so a new modeling algorithm based on NURBS Curve was proposed in this study. In detail, the new modeling algorithm is as following: Firstly transfer these discrete points, which are measured along the part’s axial lead by equal distant, into a weighting unity sequence. Secondly filter this sequence by wavelet de-noising algorithm. Thirdly replace the discrete points’ amplitudes by the corresponding weights of filtered sequence, thus yield a group of new discrete points. Lastly calculate the control vertexes and weighting factors by local rational interpolation algorithm, and construct a spatial NURBS Curve through the new discrete points to obtain the model of large-sized revolving parts’ camber. It was experimentally confirmed that this model can represent drilling stem’s camber smoothly and improve its pressure straightening precision.