With the advancement of global economic integration, traditional trade barriers have been greatly reduced, and the marginal utility of tariff reductions on trade expansion has become weaker and weaker. Especially under the global value chain division of labor system, intermediate products and parts have undergone multiple cross-border trades. The cumbersome trade procedures will greatly increase trade costs and destroy the driving force of trade. After improving infrastructure and optimizing customs clearance procedures, with the improvement of convenience, more countries and enterprises can participate in the global division of labor. Considering the industry characteristics of high-tech manufacturing, this paper selects panel data of high-tech manufacturing from multiple sample countries and uses the panel data two-way fixed-effect model to empirically analyze the impact of a country’s trade facilitation level on the global value chain of high-tech manufacturing in a country. From the perspective of global value chain status, the improvement of a country’s level of trade facilitation can significantly promote the country’s high-tech manufacturing global value chain status. The level of foreign direct investment, the degree of opening to the outside world, the level of government public services, the level of human capital, and the R&D capability are all significantly positive at the 1% level, while the level of physical capital is significantly negative at the 1% level.