Peripheral nerve injury (PNI) is a severe clinical disease leading to the loss of sensory and motor function and even lifelong disability of patients. Nerve scaffolds with conductive materials are beneficial to PNI repair and regeneration through the recovery of electrical signals transmission and regulation of nerve cell membrane function. In this study, composite poly(lactide‐co‐glycolide) (PLGA)/Ti3C2Tx (MXene) membranes with different content of MXene were fabricated by electrospinning, and these fibrous membranes showed favorable mechanical property for supporting nerve regeneration. With loaded MXene, the electrospun membranes exhibited good antibacterial property that the antimicrobial rate was as high as 80%, which is conducive to the prevention of wound inflammation after stent implantation. The loaded MXene also improved the hydrophilicity and conductivity of the electrospun composite membranes, which provided good biocompatibility for cell growth. Interestingly, treating in 75% ethanol solution made fabricated PLGA/MXene membranes rapidly crimp into stable nerve conduits for implanted application. These fabricated PLGA/MXene membranes showed good potential for nerve repair and have a good prospect for nerve conduit application.

To develop an antimicrobial membrane for wound healing, the blended k‐carrageenan (KC)/carboxymethyl chitosan (CMCH) membranes were fabricated through a freeze‐drying process together with a dual‐ion (Cu2+and K+ or Cu2+and Ca2+) crosslinking approach. The dual‐ion crosslinking by Cu2+and K+ could not only make the membranes compact but could also improve the uptake capacity and mechanical properties of the fabricated membranes. The maximum tensile stress of membranes reached up to 43 MPa and the highest swelling ratio was around 5500%, exhibiting robust moisture retention property. The CMCH and Cu2+ in blended membranes provided a good antimicrobial property against gram‐positive and gram‐negative bacteria. Moreover, the fabricated membranes showed good cytocompatibility. These results indicated the fabricated KC/CMCH membranes with dual‐ion by Cu2+ and K+ have favorable properties and have a great potential for application in wound healing.