Background: Stroke is the leading cause of mortality and disability worldwide; 87% of all deaths from stroke and 89% of all stroke-related disability-adjusted life-years occur in low- and middle-income countries. Objective: The goal of this study was to examine nurses' knowledge and practice for patient with   stroke. Methodology: Design: A cross-sectional design was used to achieve the objective of the study. Setting: Data were collected from Neurological Wards and emergency department of Al-Sadder Medical City. Sample: A non-probability (purposive) sample consisted of (60) nurses. Results: The majority of the nurses in both groups are those with age’s group between (25-29) years old and the high percentages of participants in both groups (53.3%) are females for study and control groups. Overall assessment of nurses' knowledge regarding management of patients with stroke was moderate with (0.52) mean of score. Overall evaluation of nurses' practices regarding management of patients with stroke was poor with (0.522) mean of score. Conclusion:  This study revealed the nurses' knowledge, regarding management of patients with stroke was moderate and nurses' practices regarding management of patients with stroke was poor. Recommendation:  Development and application of periodic educational and training courses for nurses regarding the management of stroke.