The polymer-bound Ming-Phos was easily prepared by the highly efficient immobilization of our recently developed Ming-Phos in polystyrene by copolymerization in the presence of 5% DVB, which shows good performance in the application of heterogeneously catalyzed asymmetric cycloaddition. A pair of enantiomers of the product with opposite configurations could be easily delivered in high yields with excellent enantioselectivity by the application of two diastereomers of the heterogeneous catalyst. This heterogeneous catalyst not only exhibits similar catalytic activity and enantioselectivity to those of the homogeneous catalyst but also could be easily recovered and recycled for up to eight cycles.

The synthesis of P-stereogenic building blocks pose extremely difficult. Herein we report an efficient kinetic resolution of secondary phosphine oxides via Le-Phos-catalyzed asymmetric allylation reaction with Morita-Baylis-Hillman carbonates. This method...

Herein, a novel and efficient gold-catalyzed intermolecular C(sp(2))-H functionalization (Friedel-Crafts alkylation) and aldol annulation strategy is presented. This cascade process allows the synthesis of a series of indanol and tetrahydronaphthalenol derivatives with two adjacent quaternary stereocenters. The attractive reaction features are the use of readily available starting materials, good diastereoselectivity, good functional-group tolerance and mild reaction conditions. Furthermore, preliminary results indicate that this transformation is amenable to enantioselectivitive synthesis with further chiral ligand screening and design.

A novel class of bifunctional cyclic phosphine catalysts (Le-Phos) is reported, which showed good performances in enantioselective γ-addition reactions of N-centered nucleophiles and allenoates under mild conditions.