Exocytosis‐inspired behavior is demonstrated in a temperature‐sensitive hybrid bi‐microcompartment system by Xin Huang and co‐workers in their Research Article on page 20795. Due to the universal loading capacity and excellent biocompatibility, proliferation and temperature‐programmed fast release of living cells were realized, thus providing a robust platform to the on‐demand transportation of various living organisms.

Inspired by the unique characteristics of living cells, the creation of life‐inspired functional ensembles is a rapidly expanding research topic, enabling transformative applications in various disciplines. Herein, we report a facile method for the fabrication of phospholipid and block copolymer hybrid bi‐microcompartments via spontaneous asymmetric assembly at the water/tributyrin interface, whereby the temperature‐mediated dewetting of the inner microcompartments allowed for exocytosis to occur in the constructed system. The exocytosis location and commencement time could be controlled by the buoyancy of the inner microcompartment and temperature, respectively. Furthermore, the constructed bi‐microcompartments showed excellent biocompatibility and a universal loading capacity toward cargoes of widely ranging sizes; thus, the proliferation and temperature‐programmed transportation of living organisms was achieved. Our results highlight opportunities for the development of complex mesoscale dynamic ensembles with life‐inspired behaviors and provide a novel platform for on‐demand transport of various living organisms.