Objective: Dyslipidemia is suggested to be one of factors that affect bone mineral density (BMD). However, epidemiological studies concerning relationship between serum lipids and BMD showed different results. Absent, positive, or negative relations have been reported.The aim of this study was to investigate the correlation between serum lipids and BMD in a group of apparently healthy Syrians. Methods:This pilot cross-sectional study was carried out at one of Damascus University Hospitals. 152 apparently healthy Syrians aged 20-50 years were enrolled. Serum cholesterol, low density lipoprotein, high density lipoprotein, and triglyceride were measured.BMD of lumbar spine, femoral neck and total hip were assessed by Dual-energy X-ray Absorptiometry (DXA) using Discovery Wi (S/N80058) scan (Hologic, Inc. Bedford, MA). Pearson correlation test was used to assess the relation between each lipid profile component and BMD of each measured skeletal site.Results: No statistically significant relationship was found between serum lipids components and BMD at any measured skeletal site. Adjustment for gender, age, smoking, and body mass index did not alter the results (P value for all was >0.05). Conclusion:Our findings do not support the hypothesis that there is a relationship between serum lipids and BMD.