Introduction: Mechanical neck pain (MNP) is a problem that can be result from various causes but it is usually result from poor or faulty posture, overuse injuries or trauma. Materials and Methods:Thirty patients with mechanical neck pain were assigned randomly into three groups: Group (A) 10 participants received conventional physical therapy program. Group (B) 10 participant received conventional physical therapy program plus natural apophyseal glides (NAGs). Group (C) 10 participant received conventional physical therapy program plus kinesio tape. Pain intensity level, neck functional disability level, and cervical range of motion were measured pre and post intervention period.Results: There was significant decrease in numerical pain rating scale and neck disability index. There was significant increase in range of motion for all groups. Conclusion:The conventional physical therapy program and NAGS are effective in improving pain intensity level, neck functional disability level, and cervical range of motion in mechanical neck pain more than the conventional physical therapy program and kinesio tape and conventional physical therapy program alone.