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Glutathione S‐transferase π (GSTπ) expression in tumor cells is thought to relate to cisplatin resistance. We attempted to clarify immunohistochemically the correlation between GSTπ expression and clinical response in ovarian cancer. Fifty‐nine patients with ovarian cancer underwent initial debulking surgery and received from three to five courses of cisplatin‐based chemotherapy after surgery. Immunostaining for GSTπ was performed on formalin fixed sections of the patients’ tumor by the streptoavidin‐biotin‐peroxidase complex method. Positive staining of GSTπ was observed diffusely in nuclei and cytoplasm of cancer cells. Of 59 tumors, 38 (64.4%) were GSTπ positive. Twenty‐three of 25 patients (92.0%) who showed no response to chemotherapy had GSTπ positive tumor cells. The predictive value of positive GSTπ staining for drug resistance was 79.3% (23/29). The 5‐year survival rate of patients with GSTπ positive tumors was significantly lower than that of those with GSTπ negative tumors by the Kaplan‐Meier method (P < 0.01). The results suggest that overexpression of GSTπ is related to resistance to cisplatin and to prognosis in patients with ovarian cancer.

Atrue collision carcinoma at the esophagogastric junction is rare. In this article, we report colliding double primary cancers of the esophagus and the stomach in a 68-year-old man and discuss this entity. Pathological analysis after total gastrectomy and partial esophagectomy showed the following findings. Areas of squamous differentiation were found on the esophageal side of the tumor and were adjacent to normal mucosa, and areas of glandular differentiation were found to the gastric side of the tumor and adjacent to normal mucosa. These two tumors collided at the esophago-cardiac junction, but there was no intermingling. In one lymph node, an independent non-intermingled metastatic adenocarcinoma and squamous cell carcinoma were observed. The pathological findings of this case satisfy rigorous criteria for collision carcinoma.