Papillary thyroid carcinoma (PTC) is the most common endocrine cancer; however, extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) of the thyroid gland is quite rare. The comorbid condition of both cancers is an infrequent event. In the present study, we report a 65-year-old woman, who underwent a thyroid ultrasound examination due to palpable thyroid nodules. The reports of the thyroid ultrasound revealed thyroiditis and the presence of multiple nodules on both lobes. Although the results revealed that biopsies were benign, total thyroidectomy was performed due to the presence of multiple nodules that may become difficult for the subsequent follow-up. Histopathological analysis exhibited the presence of papillary thyroid microcarcinomas in two foci, Hashimoto's thyroiditis accompanied with MALT lymphoma. No metastasis was found in postoperative computed tomography scans. However, bone marrow biopsy indicated uniform marginal zone lymphoma. From the result, it can be concluded that PTC and primary thyroid lymphoma may be associated with Hashimoto's thyroiditis, and for both the diseases multimodal approach is required.
Objective: The variations of thyroid hormones within normal ranges are observed in different metabolic conditions. Considering available data, levels of thyroid hormones change in obesity and type 2 diabetes mellitus (DM) in opposite ways. This study aimed to evaluate thyroid hormone levels and free triiodothyronine-to-free thyroxine (fT3/fT4) ratios in different glucose metabolism statuses of euthyroid patients with obesity. Material and Methods: This retrospective study evaluated thyroid hormones and the fT3/fT4 ratio of 209 patients with obesity who were grouped according to their glucose metabolism statuses. Results: One hundred and thirty-one (62.7%) patients had normal glucose tolerance, 41 (19.6%) patients had prediabetes, and 37 (17.7%) patients had DM. Serum fT4 level was found to be higher in patients with DM compared to patients with normal glucose tolerance (p=0.009), although no difference was observed in serum thyroid-stimulating hormone and fT3 levels among groups. FT3/fT4 ratio was determined to be lower in patients with DM than patients with normal glucose tolerance (p=0.012). Hemoglobin A1c was independently and positively associated with fT4 (β=0.345, r 2 =0.119, p=0.003) and negatively associated with fT3/fT4 ratio (β=-0.371, r 2 =0.138, p=0.001). Conclusion: Serum fT4 level increased, and fT3/fT4 ratio decreased in patients with type 2 DM independent of the degree of obesity. The interaction of DM with thyroid hormones in our cohort seemed to overcome obesityrelated changes in thyroid functions.
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