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Purpose: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure(IOP) in open angle eyes.Methods: 38 eyes of 38 patients with fibromyalgia who had open or wide open angles according to the Shaffer classification. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness(CCT), corneal endothelial cell density(CECD) and anterior chamber depth(ACD) were also recorded and evaluated. Results: No statistically significant difference was determined in IOP, CCT and CECD(p > 0.05). However, a statistically significant increase was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). Conclusion: We think that the short term use of Duloxetine does not lead to clinically significant changes despite their statistically significant effects on the anterior chamber parameters.

Purpose To evaluate the thickness of peripapillary nerve fibers in radiation-exposed healthcare workers. Method The study included 60 radiation-exposed healthcare workers and 60 healthy control groups. SD-OCT was used to measure mean peripapillary RNFL thickness along with peripapillary RNFL thickness in the upper, lower, nasal, and temporal quadrants. Results The mean age of the subjects participating in the study was 37 ± 6.3 in the radiation-exposed group and 38 ± 4.9 in the control group. The mean duration of exposure to radiation in healthcare workers was 11 ± 5 years. While the mean total rim thickness was 94.25 ± 8.2 in the radiation exposed group, it was 102.8 ± 7.4 in the control group. (p < 0.001) The mean superior rim thickness was 123.93 ± 15.13 in the radiation exposed group, was measured as 129.75 ± 14.64 in the control group. (p = 0.34) While the mean inferior rim thickness was 110.88 ± 13.43 in the group exposed to radiation, it was 130.08 ± 13.44 in the control group. (p < 0.001) The mean nasal rim thickness was 70.25 ± 9.50 in the group exposed to radiation, while it was 75.38 ± 13.77 in the control group. (p = 0.46) While the mean temporal rim thickness was 71.77 ± 8.73 in the group exposed to radiation, it was measured as 75.78 ± 13.15 in the control group. (p = 0.52). Significant thinning of nerve fiber thickness was found statistically significant in all and especially the inferior quadrants of the healthcare workers exposed to radiation compared to the control group. Conclusion After at least 5 years of radiation exposure, the thickness of the peripapillary retinal nerve fibers may decrease in healthcare workers.

Purpose: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure(IOP) in open angle eyes. Methods: 38 eyes of 38 patients with bromyalgia who had open or wide open angles according to the Shaffer classi cation. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness(CCT), corneal endothelial cell density(CECD) and anterior chamber depth(ACD) were also recorded and evaluated.Results: No statistically signi cant difference was determined in IOP, CCT and CECD(p > 0.05). However, a statistically signi cant increase was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). Conclusion:We think that the short term use of Duloxetine does not lead to clinically signi cant changes despite their statistically signi cant effects on the anterior chamber parameters.