Our findings in older physically capable men indicate that regular walking is associated with a lower overall mortality rate. Encouraging elderly people to walk may benefit their health.

No abstract

Experientia 38 (1982), Birkhguser Verlag, CH-4010 Basel/Switzerland 267 both supplemental arginine and lysine had similar growth depressing effects, only lysine had an effect on plasma cholesterol levels which became significant at the level of 4%. In addition to hypercholesterolemia, 5% lysine supplements also altered the relative ratios of high density to low density lipoproteins; a change which was due mainly to increased levels of LDL. The results of stepwise 1% supplemental increments of both arginine and lysine up to a maximum of 5% total on chick plasma cholesterol levels are presented in the figure. It can be seen that the effects of lysine on plasma cholesterol levels are only slight from 1-3% but that 4% and 5% supplementation with lysine resulted in significant hypercholesterolemia.Discussion. Arginine-lysine antagonism in the chick is a well known phenomenon l~ This antagonism affects the rate of growth, and the metabolic site of the antagonism is the kidney where a high concentration of lysine is believed to induce kidney arginase activity. However, since in both mammals and birds the liver is the major site of lipoprotein metabolism and since compared to mammals only trace amounts of arginase are present in the chicken liver, it is not clear whether lipoprotein metabolism would be affected by arginine-lysine antagonism in the chick. Our results from chicks fed supplemental crystalline lysine and arginine show that, as in ureotelic mammals, excess dietary lysine does stimulate hypercholesterolemia. It can be concluded, therefore, that the cholesterolemic effects of arginine-lysine imbalance are not mediated by urea cycle anaplerosis.