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Examination of the crystals revealed small irregular friable white masses. Microscopically these were made up of rather easily broken up bundles of long pointed wedge-shaped, some¬ times notched, colorless crystals. On treatment with acid and azotization they gave a typical reaction for sulfapyridine. Mor¬ phologically these crystals resembled the crystals from a kidney (case 1) which were identified as sulfapyridine ( fig. 4). SUMMARY AND CONCLUSIONS 1. Two patients had renal calculi after sulfapyridine treatment, proved at postmortem examination and by pyelography, respectively. Both patients had hematuria and one also had renal colic. One had had only 11 Gm. of the drug and the other 555 Gm.2. Pyelograms in one of the cases showed calculi, nonopaque to x-rays. The serial study indicates that later the calculi dissolved or were washed out and the kidney function returned to normal.3. The features of these two cases, together with the experimental studies reported by other investigators, indicate that hematuria and other urinary symptoms occurring after sulfapyridine administration are caused by the deposition of sulfapyridine crystals and con¬ cretions in the kidneys and ureters.