Tomato plants are the second important vegetable crop grown in Egypt. Insect pests pose a serious threat in vegetable production both in terms of quality and quantity. Order Lepidoptera is one of the larger orders in insects. The cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) and the leaf miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) are the most serious lepidopterous insect attaching the tomato crop. Pesticides are the basis for defending against major biological disasters and important for ensuring national food security. Nano materials motivate the toxicity of pesticides. In this study the pesticide Marsa 24% SC (belongs to Methoxyfenozide) used for controlling S. littoralis, while Calazole 2% EC (Emamectin Benzoate) applied on T. absoluta. Each pesticide will apply with and without nano cupper complexe salt (1-(2-bromophenyl)-1λ 4-diazane hexadecyltrimethyl-1λ 4-azane, bromo trichloro cuprate (II). Results indicated that the addition of nano salt increases the mortality percentage for both pests (22.45, 59.22 to 100 %) and decreases the lethal time (10 to 3 days; 13 to 4 days) comparing with pesticides without nano salt.