Background: Laparoscopic sleeve gastrectomy (LSG) is the most commonly performed bariatric operation in Egypt. To the best of our experience there is no published data in Egypt regarding the results of Histopathological examination of the resected gastric specimen after LSG. Objective: To find the range of gastric pathologies in the resected specimens and trying to answer the question whether the resected specimen after LSG should be sent for Histopathological examination or not? Methods: Data were collected prospectively from the period from February 2014 till May 2017 and included 211 patients. LSG was performed by the bariatric team of our department using the same technique. The resected specimen was sent to the pathology department of our institute for pathological examination. Results: the mean age of the studied patients was 36 ± 11.8 years with mean BMI of 44.1 ± 4.7 Kg/m 2 , and female patients represents 67.8% of the studied patients. Chronic nonspecific gastritis was the most common Histopathological finding and was present in 52.1% of patients, normal histopathology was present in 25.6% of patients, and Helicobacter Pylori (HP) related gastritis was present in19.9 % of patients, gastrointestinal stromal tumor (GIST) was present in 4 (1.9%) cases, and we have 1 case of healed cicatrized ulcer. Conclusion: Benign lesions accounts for 98.1% of the studied patients signifying the non-importance of routine pathological examination of the resected specimen after LSG and should only be done in case of grossly suspected lesions. Preoperative esophagogastroduodenoscopy (EGD) may be advised before surgery.