Background: in chronic kidney disease (CKD) patients, there is a loss of muscle mass due to chronic inflammation, nutritional deficiencies, and metabolic acidosis, these factors lead to decreased physical fitnessand poor clinical outcomes. Handgrip strength (HGS) is an index for physical function, the aim of our study   was to investigate the relationship between CKD and handgrip strength (HGS) in Ha'il, Saudi Arabia. Methods: We conducted a cross-sectional study consisting of 251 CKD patients in Ha'il, Saudi Arabia.132 males and 119 females, aged between 25 and 65 years. Renal function (creatinine, and blood urea nitrogen) and Hand grip strength (HGS) were recorded for all patients. Results: 3.2 kg/BMI for males and 1.8 kg/BMI for women were the average relative HGS (kg/BMI). In both sexes, HGS was inversely correlated with age and height and positively correlated with body weight and BMI, whereas the opposite was true for relative HGS. Conclusions: Relative HGS is an effective way to quantify muscle strength in chronic renal disease patients based on their body mass. As a result, relative HGS may be a valuable and cost-effective method for the detection of kidney disorders that are chronic in nature.