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In this study, the antimicrobial effect of bitter almond (Amygdalus nana L.) and sweet almond (Amygdalus trichamygdalus) extract were investigated. The extracts of the sweet almond which plants collected from Diyarbakır Ergani district and the extracts of the bitter almond which plants collected from Van Tuşba district. The almonds dissolved in deionized water, alcohol, and ether. Fungus, gram positive and gram negative bacteria were used as pathogens in this study. The effects of the extracts on pathogens were determined by using the disk diffusion method. According to the zones that were formed by almond extract against bacteria; The highest inhibitory effect of the extract of Amygdalus nana L. (Bitter Almond) showed the highest inhibitory effect on Enterococcus faecalis and the extract of Amygdalus trichamygdalus (Sweet Almond) on Staphylococcus aureus and Escherichia coli.