Abstract. A mild, efficient, and practical method for one-step synthesis of alkanoyl and aroyl isothiocyanates from carboxylic acids using a safe and inexpensive mixed reagent, trichloroisocyanuric acid/triphenylphosphine is described at room temperature. Availability of the reagents and easy workup of the reaction make this method attractive for organic chemists.

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An efficient mixed reagent for direct synthesis of symmetrical carboxylic anhydrides from carboxylic acids has been prepared. Carboxylic acids are converted to anhydrides using triphenylphosphine/trichloroisocyanuric acid under mild reaction conditions at room temperature. Short reaction time, excellent yields of products, low cost, availability of reagents, simple experimental procedure, and easy work-up of the products are the main advantages of the presented method.

Triphenylphosphine (PPh 3 ) / N-chlorobenzotriazole (NCBT), and amine (primary and secondary aliphatic amines and also substituted anilines) in CH 2 Cl 2 efficiently converted carboxylic acids, α-amino acids and sulfonic acids to the corresponding amides and sulfonamides at room temperature. Good to excellent yields, inexpensive, and fast reaction conditions are the important features of this procedure. Downloaded by [University of Otago] at 07:23 24 July 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2