Background The complete lockdown caused by the COVID-19 pandemic had imposed a new behavior and lifestyle especially in terms of diet, physical activity, and the management of patients with chronic diseases. Aim The present study aimed to analyze the impact of lockdown on the monitoring and care of type 2 diabetes mellitus (T2DM) patients in a Moroccan population from the Doukkala region. Subjects and methods We conducted a retrospective observational study including 121 T2DM patients recruited from the Diabetes Diagnosis and Treatment Center of El Jadida city. Demographic, anthropometric, and biochemical data of our T2DM patients were recorded before and after lockdown that lasted 82 days. All patients have signed an informed consent after being informed about the purely scientific aims of the study. Results Our sample involved 84 women and 37 men with an age average of 57.31 ± 0.91 years. The effects of lockdown were more marked in women than in men: women showed a significant tendency to gain weight (from 78.13 ± 1.36 kg to 81.80 ± 1.45 kg; p -value < 0.000), that impacted the body mass index ( p -value < 0.000); they also showed significant increases in HbA1c values ( p -value = 0.001), significant decrease in systolic blood pressure ( p -value = 0.0302) and a surprising increase in high-density lipoprotein cholesterol ( p -value = 0.0132). The prevalence of metabolic syndrome in the women sample increased from 46.4% to 54.8% after the lockdown. In men, the negative effect of lockdown was observed only in HbA1c that values increased significantly from 8.66 ± 0.21% to 9.51 ± 0.25% ( p -value = 0.0127). Conclusion Our results reveal that lockdown had impacted negatively the health status of T2DM patients, especially women. We suggest an urgent development of programs aiming to improve the hygiene of life and to reduce the impact of future crises on patients suffering chronic diseases such as T2DM.

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In Morocco, there are very few studies on the use of drugs and even less on psychotropic medicines (MPSYC). In this study we identified the misuse of MPSYC and their sources of supply in order to determine their modes of consumption and also assess the consumers health status. Methods. An anonymous survey of 500 MPSYC consumers was conducted in Casablanca. Data entry and statistical analysis were carried out using SPSS 25.0 software.Results: 500 participants in the survey were poly-drug users of MPSYC with an average of 4.13 ± 0.007 (± SEM) drugs per user. The most misused MPSYC are Clonazepam, Diazepam, Nordazepam and Tramadol with respective prevalences of 96.80%, 82%, 55.60% and 47.80%. A statistical analysis showed that clonazepam (p=0.047) and tramadol (p=0.005) are prevalent in the street market. 54.20% of survey participants use MPSYC once a week while 39.80% of them use it twice a week. The same statistical analysis revealed that taking several MPSYC lead to an increase of ingested doses (p<0.001) and alcohol consumption (p=0.003). 96.40% (n=482) of the participants declared that they had experienced discomfort misusing the medicine.